| ncRNA name | hsa-miR-34a |
| ncRNA Category | miRNA |
| Disease name | retinoblastoma (RB) |
| Species | Homo sapiens |
| Tissues/Cell_line | human RB cell lines Y79, WERI-RB1 and HCT116 |
| Methods | transfection, RNAi, luciferase reporter assay, Western blot, qRT-PCR |
| Expression pattern | down-regulated |
| Functional description | MIR34A inhibits HMGB1 expression through a direct MIR34A-binding site within the HMGB1 3' untranslated region. MIR34A inhibition of HMGB1 leads to a decrease in autophagy under starvation conditions or chemotherapy treatment. |
| PubMed ID | 24418846 |
| Year | 2014 |
| Title | MIR34A regulates autophagy and apoptosis by targeting HMGB1 in the retinoblastoma cell. |
| Drug-related ncRNA | NO |
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